UK researchers change blood type of donor kidneys

By Karim El-Bar

LONDON (AA) - British researchers have altered the blood type of donor kidneys in a scientific breakthrough that could increase the supply of kidneys for those waiting for a transplant, researchers at the University of Cambridge announced on Monday.

The breakthrough is of particular significance for British ethnic minorities who are less likely to find compatible kidney donations.

There are low levels of kidney donations among British ethnic minorities. A third of those on kidney transplant lists in 2020-21 were ethnic minorities, with around 9% of overall organ donations coming from ethnic minorities.

University of Cambridge researchers found a way to change the blood type to universal O, which can be used with any blood type.

Mike Nicholson of transplant surgery at the University of Cambridge, explained: “One of the biggest restrictions to who a donated kidney can be transplanted to is the fact that you have to be blood group compatible."

“The reason for this is that you have antigens and markers on your cells that can be either A or B. Your body naturally produces antibodies against the ones you don’t have. Blood group classification is also determined via ethnicity and ethnic minority groups are more likely to have the rarer B type.”

Serena MacMillan, a Ph.D., student at the University of Cambridge, said: “By taking B type human kidneys and pumping the enzyme through the organ using our normothermic perfusion machine, we saw in a matter of just a few hours that we had converted a B type kidney into an O type. It’s very exciting to think about how this could potentially impact so many lives.”

The research was funded by the charity Kidney Research UK, and is due to be published in the British Journal of Surgery.